Elemental Derangement Analysis Through Panchapatchi Sasthiram In Patients With Alzheimer’s Disease

Research Paper | 2026 | Volume 1 | Issue 02 | Page 21-31

Thangagomathi K ¹ , Sowmiya V² , Balamurugan A³ , Sundararajan S ⁴

^1,2PG scholar, ³Associate professor Department of Noinadal , ⁴ Head of the Department of Noinadal, Government Siddha medical College and hospital, Palayamkottai, Tirunelveli

Elemental Derangement Analysis Through Panchapatchi Sasthiram In Patients With Alzheimer’s.

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Corresponding Author:- 

Thangagomathi K, PG Scholar, 

Department of Noinadal

Government Siddha medical College 

and hospital, Palayamkottai, Tirunelveli

Gmail- thangagomathi16@gmail.com

ABSTRACT

Alzheimer’s disease is a progressive neurodegenerative disorder characterized by gradual deterioration of memory, cognition, and functional abilities, imposing a major clinical and socioeconomic burden worldwide. Early identification of susceptible individuals remains challenging because advanced diagnostic modalities are expensive and often inaccessible in resource-limited settings. Siddha medicine describes neurocognitive disorders through the concepts of Mukkutram, Bootham, and constitutional predisposition, while Panchapatchi Sasthiram provides a traditional chronobiological framework for evaluating elemental and humoral imbalance. The present study was undertaken to analyse elemental derangements through Panchapatchi Sasthiram in patients with Alzheimer’s disease and to explore its relevance as a supportive diagnostic approach. A cross-sectional observational study was conducted among 50 patients above 50 years of age attending the outpatient department of Noi Naadal at Government Siddha Medical College and Hospital, Palayamkottai. Cognitive impairment was assessed using standardized Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scales. Panchapatchi calculations were performed based on birth star, lunar phase, birth Patchi, and associated Bootham to determine humoral predominance and affected Mandalam. The findings revealed predominance of Theipirai birth phase (56%) and Vallooru birth Patchi (50%) among the participants. Vatha–Pitham (48%) and Pitha–Vatham (38%) were the most common humoral derangements observed. Aakinai Mandalam showed maximum involvement during both Thuyil and Saavu states, indicating predominant disturbance in higher neurological functions. Significant involvement of Manipooragam Mandalam also suggested an associated metabolic contribution to neurodegenerative progression. The observed association between Vallooru predominance, Vaatha aggravation, and neurological deterioration supports the Siddha concept that constitutional elemental imbalance may influence susceptibility to cognitive decline. The study highlights the potential utility of Panchapatchi Sasthiram as a simple, non-invasive, and cost-effective complementary diagnostic approach for evaluating elemental and humoral derangements in Alzheimer’s disease. Further large-scale clinical studies are necessary to validate these preliminary observations and establish their diagnostic significance in neurodegenerative disorders.

Keywords - Alzheimer’s disease, Panchapatchi Sasthiram, Humoral derangement, Siddha medicine, Neurodegenerative disorders